The DYRK1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DYRK1A. This antibody recognizes Human, Mouse, and Rat antigen. The DYRK1 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Overview: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.
Structure: The polyhistidine repeats act as targeting signals to nuclear speckles.
Expression: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney